Nanoparticles in the Lung

Introduction. Deposition. Interaction with the Lung Surface. Role of the Biomolecule Corona in Nanoparticle Fate and Behavior. Interaction with Alveolar Lining Fluid. Interaction with Lung Macrophages. Interactions with Alveolar Epithelium. Mechanistic Aspects of Cellular Uptake. Cellular Uptake and Intracellular Trafficking. Translocation across the Air-Blood Tissue Barrier. The Pulmonary Lymphatic System. Translocation and Accumulation in the Body. Practical Considerations for Drug Delivery to the Respiratory Tract. Drug and Gene Delivery in the Lungs. Bio-Nanocapsules: Novel Drug Delivery. Physicochemical, Colloidal, and Transport Properties. Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore. Potential for Nose-to-Brain Delivery of Drugs. The Developing Lungs. Nanotoxicology. Summary.

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• Nanotecnologia
• Ciência dos materiais
• Medicina pré-clínica: ciências básicas
• Biotecnologia
• Física
• Engenharia biomédica

respiratory toxicology;pulmonary pharmacology;epithelial cell transport;inhalation exposure assessment;cellular uptake mechanisms;advanced nanomedicine applications;nanoparticle biodistribution in lungs